The Analysis of the Relationship Between A1298C and C677T Polymorphisms of theMTHFRGene with Prostate Cancer in Eskisehir Population
Autor: | Derya Uzun, Mehmet Turgut, Ahmet Uludag, Selma Demir, Muhammed Hamza Müslümanoğlu, Emre Tepeli, Kemal Murat Canturk, Engin Atli, Muhsin Özdemir |
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Rok vydání: | 2009 |
Předmět: |
Male
Oncology medicine.medical_specialty Turkish population Turkey Population Prostate cancer Prostate Internal medicine medicine Humans Allele education Allele frequency Methylenetetrahydrofolate Reductase (NADPH2) Genetics (clinical) Aged DNA Primers Aged 80 and over Gynecology education.field_of_study Polymorphism Genetic Base Sequence biology Prostatic Neoplasms General Medicine Middle Aged medicine.disease Genotype frequency medicine.anatomical_structure Methylenetetrahydrofolate reductase biology.protein |
Zdroj: | Genetic Testing and Molecular Biomarkers. 13:641-645 |
ISSN: | 1945-0257 1945-0265 |
DOI: | 10.1089/gtmb.2009.0046 |
Popis: | Prostate cancer is the most common cause of cancer deaths in men and is a major health problem worldwide. Methylene tetrahydrofolate reductase (MTHFR) plays an important role for folate metabolism and is also an important source for DNA methylation and DNA synthesis (nucleotide synthesis). The objective of this study was to investigate the relationship between the A1298C and C677T polymorphisms of the MTHFR gene and prostate cancer in the Turkish population. In our study, 93 prostate cancer patients between the ages of 50-89 and a control group of 166 benign prostate hyperplasia patients were evaluated. C677T and A1298C polymorphism ratios were compared among these two groups, and an analysis was made to see if there is a statistically meaningful difference. In this study, it has been observed that C677T polymorphism of the MTHFR gene produces no statistically significant difference for T allele frequency and the genotype frequency in prostate cancer patients and male controls with benign prostate hyperplasia not having prostate cancer, whereas it has been observed that A1298C polymorphism produces a statistically significant difference for C allele frequency in prostate cancer patients and controls and that it also produces a statistically marginal significance for genotype frequencies. |
Databáze: | OpenAIRE |
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