Intraparenchymal Application of Mature B Lymphocytes Improves Structural and Functional Outcome after Contusion Traumatic Brain Injury
| Autor: | Mark C. Poznansky, Joon Yong Chung, William J Edmiston, Michael J. Whalen, Ruxandra F. Sîrbulescu, Sonya A. Poznansky |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
B-Lymphocytes 030506 rehabilitation Pathology medicine.medical_specialty business.industry Traumatic brain injury Brain Contusion Inflammation Recovery of Function medicine.disease Mice Inbred C57BL Cerebral contusion Mice 03 medical and health sciences 0302 clinical medicine Immune system Animals Medicine Neurological dysfunction Neurology (clinical) medicine.symptom 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma. 36:2579-2589 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2018.6368 |
| Popis: | Cerebral contusion causes neurological dysfunction mediated in part by inflammatory responses to injury. B lymphocytes are dynamic regulators of the immune system that have not been systematically studied in traumatic brain injury (TBI). We showed previously that topically applied mature B cells have immunomodulatory properties and strongly promote tissue regeneration, including cutaneous nerve growth, in acute and chronic skin wounds. Using a mouse controlled cortical impact (CCI) model, we assessed a possible beneficial role of exogenously applied B cells on histopathological and functional outcome after TBI. Mice were injected intraparenchymally at the lesion site with 2 × 10 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|