Evaluation of acyclovir cream and gel formulations for transdermal iontophoretic delivery
| Autor: | Vishal Sachdeva, Phillip M. Friden, Ajay K. Banga, Srujana Siddoju |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Microdialysis Materials science Iontophoresis Chemistry Pharmaceutical Hydrophobic drug Pharmaceutical Science Acyclovir Pharmacology Administration Cutaneous Polyvinyl alcohol Antiviral Agents Hairless Rats Ointments chemistry.chemical_compound Drug Delivery Systems chemistry In vivo Drug delivery Animals Gels Transdermal |
| Zdroj: | Therapeutic delivery. 3(3) |
| ISSN: | 2041-5990 |
| Popis: | Background: Efficient iontophoretic transdermal delivery of hydrophilic drug molecules requires selection of appropriate aqueous formulation. In this study, oil/water cream and gel formulations were investigated for iontophoretic transdermal delivery of acyclovir (ACV), a model hydrophilic small-drug molecule, across hairless rat skin on Franz diffusion cells. Results: Iontophoresis (0.2 mA/cm2) enhanced ACV delivery from both 5% cream (pH 6.8) and 4% gel (pH 11) formulations. However, sixfold higher drug levels were delivered across the skin using gel formulation (12.25 ± 4.04 µg/cm2) as compared with cream formulation (2.03 ± 0.05 µg/cm2). Significantly higher drug levels were delivered when iontophoresis was performed at higher current density (0.32 mA/cm2; p < 0.05). Influence of formulation co-solvents (glycerin and propylene glycol) on drug delivery was also investigated in vitro using Franz cells and in vivo in hairless rats using microdialysis. Conclusion: Iontophoretic transdermal delivery of ACV was feasible and dependent on the selection of formulation components and delivery parameters. |
| Databáze: | OpenAIRE |
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