Serum Levels of Interleukin-2 in Patients with Alopecia Areata: Relationship with Clinical Type and Duration of the Disease
| Autor: | Nermina Ovcina-Kurtovic, Emina Kasumagic-Halilovic, Lamija Zecevic, Semra Cavaljuga |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Interleukin 2 medicine.medical_specialty medicine.medical_treatment Dermatology medicine.disease_cause Gastroenterology Autoimmunity Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine business.industry Alopecia areata medicine.disease 030104 developmental biology Hair loss medicine.anatomical_structure Cytokine Scalp Etiology Original Article business medicine.drug |
| Zdroj: | Skin Appendage Disorders. 4:286-290 |
| ISSN: | 2296-9160 2296-9195 |
| DOI: | 10.1159/000486462 |
| Popis: | Background: Alopecia areata (AA) is a disease characterized by focally, nonscarring hair loss on the scalp or any hair-bearing surface. The etiology is unknown, although the evidence suggests that AA is an immunologically mediated disease. In the pathogenesis of AA, Th1 immune response is predominant. A special cytokine profile is created by Th1 cells, which disturbs the natural balance of the cytokine networks and leads to inflammatory reaction and follicle damage. Objective: The aim of our study was to evaluate serum concentrations of IL-2 in patients with AA and healthy subjects. We also examined a possible association between serum levels of IL-2, disease severity, and duration of AA. Methods: Sixty patients with AA and 20 healthy controls were enrolled in the study. Serum concentrations of IL-2 were measured using enzyme-linked immunoassay techniques. Results: Comparison of mean values of IL-2 has showed that serum concentrations of this cytokine are significantly higher in serum samples of AA patients in relation to the control group (22.2 ± 1.19 vs. 21.1 ± 2.68 pg/mL, respectively; p = 0.0142). No correlations were found between clinical type, duration of the disease, and serum levels of IL-2. Conclusion: Our findings support the evidence that elevation of serum IL-2 is associated with AA. The exact role of serum IL-2 in AA should be additionally investigated in future studies. |
| Databáze: | OpenAIRE |
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