Plasma Pentraxin 3, but not High-sensitivity C-reactive Protein, is a Useful Inflammatory Biomarker for Predicting Cognitive Impairment in Elderly Hypertensive Patients
| Autor: | Yuichiro Yano, Yuichiro Sato, Shuntaro Matsuda, Kazuomi Kario, Kinta Hatakeyama, Yujiro Asada, Tatuhiko Kodama, Takuroh Imamura, Kazuyuki Shimada |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Aging medicine.medical_specialty Body Mass Index Risk Factors Weight loss Internal medicine Weight Loss medicine Humans Dementia Aged Ultrasonography Psychiatric Status Rating Scales Mini–Mental State Examination biology medicine.diagnostic_test business.industry C-reactive protein medicine.disease Serum Amyloid P-Component C-Reactive Protein Carotid Arteries Cross-Sectional Studies Blood pressure Hypertension Ambulatory biology.protein Cardiology Physical therapy Biomarker (medicine) Female Geriatrics and Gerontology medicine.symptom Cognition Disorders business Body mass index Biomarkers |
| Zdroj: | The Journals of Gerontology: Series A. :547-552 |
| ISSN: | 1758-535X 1079-5006 |
| Popis: | BACKGROUND: Due to the increasing longevity of human populations worldwide, there is need of a useful biomarker for the early detection of cognitive impairment in elderly persons. Both high blood pressure (BP) and inflammatory processes have been reported to be involved in cognitive impairment via cerebrovascular atherosclerosis or neuronal cell damage. METHODS: In this cross-sectional study of 210 ambulatory elderly hypertensive patients without clinically evident dementia (mean age: 74 years; 44% men), we measured 24-hour BP, circulatory pentraxin 3 (PTX3) and high-sensitivity C-reactive protein (hs-CRP) levels, and cognitive function (Mini-Mental State Examination [MMSE]). RESULTS: A high plasma PTX3 level was observed in lean subjects, especially in those whose current body weight was lower than that measured 5 years earlier, whereas a high hs-CRP level was associated with obesity (all p < .05). Both PTX3 and hs-CRP levels were significantly associated with the MMSE score (r = -.248, p |
| Databáze: | OpenAIRE |
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