Long-term benefits and adverse effects of intermittent versus daily glucocorticoids in boys with Duchenne muscular dystrophy

Autor: Valeria, Ricotti, Deborah A, Ridout, Elaine, Scott, Ros, Quinlivan, Stephanie A, Robb, Adnan Y, Manzur, Francesco, Muntoni, E, Scott
Rok vydání: 2012
Předmět:
Zdroj: Journal of neurology, neurosurgery, and psychiatry. 84(6)
ISSN: 1468-330X
Popis: OBJECTIVE To assess the current use of glucocorticoids (GCs) in Duchenne muscular dystrophy in the UK, and compare the benefits and the adverse events of daily versus intermittent prednisolone regimens. DESIGN A prospective longitudinal observational study across 17 neuromuscular centres in the UK of 360 boys aged 3-15 years with confirmed Duchenne muscular dystrophy who were treated with daily or intermittent (10 days on/10 days off) prednisolone for a mean duration of treatment of 4 years. RESULTS The median loss of ambulation was 12 years in intermittent and 14.5 years in daily treatment; the HR for intermittent treatment was 1.57 (95% CI 0.87 to 2.82). A fitted multilevel model comparing the intermittent and daily regiments for the NorthStar Ambulatory Assessment demonstrated a divergence after 7 years of age, with boys on an intermittent regimen declining faster (p
Databáze: OpenAIRE