Pharmacological analysis of response latency in the hot plate test following whole-body static magnetic field-exposure in the snail Helix pomatia
| Autor: | János F. László, László Hernádi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Tryptamine
medicine.medical_specialty Serotonin Hot Temperature (+)-Naloxone chemistry.chemical_compound Internal medicine medicine Reaction Time Animals Radiology Nuclear Medicine and imaging Drug Interactions Hot plate test Latency (engineering) Radiological and Ultrasound Technology biology Behavior Animal Helix Snails Antagonist Helix pomatia biology.organism_classification Circadian Rhythm Analgesics Opioid Nociception Endocrinology Magnetic Fields chemistry Anesthesia |
| Zdroj: | International journal of radiation biology. 90(7) |
| ISSN: | 1362-3095 |
| Popis: | To study the effect of single, 30-min long, whole-body, homogeneous static magnetic field (SMF)-exposure of magnetic induction 147 ± 3 mT on the response latency of the snail Helix pomatia.The response was investigated using the hot plate test.The effect caused by exposure to SMF was compared to sham-exposure and resulted in significant differences (up to 47.1%, p0.001). The response latency depended on the day-night cycle; response latency was higher by 51.2% (p0.001) during the night. This trend also held for SMF-exposure (28.6%, p0.001). Serotonin alone increased response latency (55.7%, p0.001), whereas serotonin antagonist tryptamine decreased it (- 97.8%, p0.001). Using naloxone, response latency decreased (- 52.5%, p0.001); however both SMF-exposure and serotonin in combination with naloxone rose it back to above the control level (116.9%, p0.001 or 150.2%, p0.001, respectively).This study provides evidence that SMF-exposure mediates peripheral thermal nociceptive threshold by affecting the serotonerg as well as the opioiderg system. |
| Databáze: | OpenAIRE |
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