Admission glucose, fasting glucose, HbA1c levels and the SYNTAX score in non-diabetic patients undergoing coronary angiography
| Autor: | Margalit Zlotnik, Shmuel Banai, Shlomo Berliner, Itay Rabinovich, Amir Halkin, Itzhak Herz, Ariel Finkelstein, Gad Keren, Shmuel Bazan, Yaron Arbel, Ofer Havakuk |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Myocardial Infarction Coronary Artery Disease Coronary Angiography Risk Assessment Severity of Illness Index Angina Coronary artery disease Patient Admission Predictive Value of Tests Risk Factors Internal medicine Diabetes mellitus Severity of illness Odds Ratio medicine Humans Angina Stable Prospective Studies Registries Israel Risk factor Prospective cohort study Aged Aged 80 and over Glycated Hemoglobin business.industry Fasting General Medicine Odds ratio Middle Aged medicine.disease Logistic Models Predictive value of tests Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Clinical Research in Cardiology. 103:223-227 |
| ISSN: | 1861-0692 1861-0684 |
| DOI: | 10.1007/s00392-013-0641-7 |
| Popis: | Pre-diabetic state is a major risk factor for the development of diabetes and cardiovascular events. Admission glucose, fasting glucose and HbA1c levels have an effect on prognosis in patients with pre-diabetes and in non-diabetic individuals. The aim of the present study was to investigate which of the following glucometabolic markers (admission glucose, fasting glucose and HbA1c levels) is correlated with the severity of coronary artery disease (CAD) in non-diabetic patients.CAD severity according to SYNTAX score was prospectively evaluated in 226 non-diabetic patients hospitalized with myocardial infarction or stable angina and underwent coronary angiography. Glucose intolerance was assessed by serum admission glucose, fasting glucose and HbA1c levels. Logistic regression analysis was used to evaluate which glucometabolic factor has the strongest correlation with CAD severity.HbA1c was the only glucometabolic factor associated with SYNTAX score above 22 (OR = 3.03, CI 95% 1.03-8.9, p = 0.04). HbA1c was also significantly associated with CAD severity in subgroup analysis (MI and stable angina).In non-diabetic patients with myocardial infarction or stable angina, HbA1c levels correlate with CAD severity as measured by the SYNTAX score. No correlation was found between admission glucose or fasting glucose levels and CAD severity. |
| Databáze: | OpenAIRE |
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