Long-Term Effects of Inhaled Budesonide for Bronchopulmonary Dysplasia
| Autor: | Dirk, Bassler, Eric, S Shinwell, Ikko, Hallman, Pierre-Henri, Jarreau, Richard, Plavka, Virgilio, Carnielli, Christoph, Meisner, Corinna, Engel, Alexander, Koch, Karen, Kreutzer, Johannes, N van den Anker, Matthias, Schwab, Henry, L Halliday, Christian, F Poets, Nobile, Stefano, Neonatal European Study of Inhaled Steroids Trial Group |
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| Přispěvatelé: | Pediatric Surgery, Eckstein, Anja (Beitragende*r), Felderhoff-Müser, Ursula (Beitragende*r), Hobrecht, Julia (Beitragende*r), University of Zurich, Bassler, Dirk, Clinicum, Children's Hospital, HUS Children and Adolescents |
| Rok vydání: | 2018 |
| Předmět: |
Budesonide
Pediatrics medicine.medical_specialty Medizin Neurosis 610 Medicine & health 2700 General Medicine Placebo Birth-weight infants Bayley Scales of Infant Development Trial Cerebral palsy law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial 3123 Gynaecology and paediatrics law 030225 pediatrics medicine 030212 general & internal medicine Glucocorticoids Inhalation business.industry Prevention Gestational age General Medicine 10027 Clinic for Neonatology medicine.disease N/A Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA Bronchopulmonary dysplasia Steroids business medicine.drug |
| Zdroj: | New England Journal of Medicine, 378(2), 148-157. Massachussetts Medical Society |
| ISSN: | 0028-4793 |
| DOI: | 10.1056/nejmoa1708831 |
| Popis: | Background The long-term effects on neurodevelopment of the use of inhaled glucocorticoids in extremely preterm infants for the prevention or treatment of bronchopulmonary dysplasia are uncertain. Methods We randomly assigned 863 infants (gestational age, 23 weeks 0 days to 27 weeks 6 days) to receive early (within 24 hours after birth) inhaled budesonide or placebo. The prespecified secondary long-term outcome was neurodevelopmental disability among survivors, defined as a composite of cerebral palsy, cognitive delay (a Mental Development Index score of |
| Databáze: | OpenAIRE |
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