Two inhibitors of angiotensin‐converting enzyme, enalapril and captopril, increase salt appetite of rats
| Autor: | Bagdon Wj, David H. Minsker, Bokelman Dl, Richard T. Robertson |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Captopril Proline medicine.medical_treatment media_common.quotation_subject Drinking Angiotensin-Converting Enzyme Inhibitors Sodium Chloride Pharmacology Toxicology Food Preferences Enalapril Pregnancy Oral administration Internal medicine medicine Animals Saline media_common biology Chemistry Seminal Vesicles Rats Inbred Strains Angiotensin-converting enzyme Appetite Dipeptides Pollution Rats Fertility Endocrinology Enzyme inhibitor ACE inhibitor biology.protein Female medicine.drug |
| Zdroj: | Journal of Toxicology and Environmental Health. 14:715-722 |
| ISSN: | 0098-4108 |
| Popis: | Male rats were orally administered an inhibitor of angiotensin-converting enzyme (ACE), N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-1-ala-1-pro maleate (enalapril, MK-0421) at dosage levels of 10, 30, and 90 mg/kg X d. After 2-6 wk of dosing, the rats receiving 30 and 90 mg/kg X d produced large numbers of seminal plugs and had lacerated penises due to licking in an attempt to recover urine. Providing 0.9% saline as the source of drinking water prevented this behavior and subsequent lesions. There were no adverse effects on reproductive performance. A subsequent study showed that enalapril at 5 mg/kg X d po and captopril (another ACE inhibitor) at 25 mg/kg X d po increased NaCl intake in rats. Our results with captopril confirm those of Fregly (1980) and Evered and Robinson (1983) and show that both converting-enzyme inhibitors (enalapril and captopril) increase salt appetite in rats. |
| Databáze: | OpenAIRE |
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