Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery
| Autor: | Che Hao Hsu, Yi Wen Lin, Chih-Yuan Lin, Go-Shine Huang, Yi-Ting Tsai, Chien Sung Tsai, Tso-Chou Lin, Zhi-Fu Wu, Feng Yen Lin, Chi Yuan Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Article Subject Immunology Enzyme-Linked Immunosorbent Assay Pulmonary Dysfunction law.invention law lcsh:Pathology Cardiopulmonary bypass Medicine Humans Cardiac Surgical Procedures Aged Aged 80 and over Cardiopulmonary Bypass business.industry Matrix metalloproteinase 9 Cell Biology Perioperative Oxygenation Middle Aged Cardiac surgery surgical procedures operative Matrix Metalloproteinase 9 Anesthesia Arterial blood Female business PULMONARY INFILTRATION lcsh:RB1-214 Research Article circulatory and respiratory physiology |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2015 (2015) |
| ISSN: | 0962-9351 |
| DOI: | 10.1155/2015/341740 |
| Popis: | Background. Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB.Methods. Thirty patients undergoing elective cardiac surgery were included. Arterial blood was sampled at 6 sequential points (before anesthesia induction, before CPB and at 2, 4, 6, and 24 h after beginning CPB) for plasma MMP-9 concentrations by ELISA. The perioperative laboratory data and variables, including bypass time, PaO2/FiO2, and extubation time, were also recorded.Results. The plasma MMP-9 concentrations significantly elevated at 2–6 h after beginning CPB (P<0.001) and returned to the preanesthesia level at 24 h (P=0.23), with predominant neutrophil counts after surgery (P<0.001). The plasma MMP-9 levels at 4 and 6 h were not correlated with prolonged CPB time and displayed no association with postoperative PaO2/FiO2, regardless of reduced ratio from preoperative342.9±81.2to postoperative207.3±121.3 mmHg (P<0.001).Conclusion. Elective cardiac surgery with CPB induced short-term elevation of plasma MMP-9 concentrations within 24 hours, however, without significant correlation with CPB time and postoperative pulmonary dysfunction, despite predominantly increased neutrophils and reduced oxygenation. |
| Databáze: | OpenAIRE |
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