Evaluation of serum vitamin B12 levels in type 1 diabetics attending a tertiary care hospital: A preliminary cross – sectional study
| Autor: | Vageesh Ayyar, Prasanna Kumar, Ann Sarah Koshy, S Jaya Kumari |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Cross-sectional study type 1 diabetes Endocrinology Diabetes and Metabolism Population lcsh:Diseases of the endocrine glands. Clinical endocrinology Endocrinology Internal medicine Diabetes mellitus medicine Vitamin B12 lcsh:RC799-869 education diabetic control education.field_of_study Type 1 diabetes lcsh:RC648-665 business.industry Tertiary care hospital duration of diabetes medicine.disease Surgery Vitamin B12 deficiency lcsh:Diseases of the digestive system. Gastroenterology Original Article business Serum vitamin b12 Diabetic control |
| Zdroj: | Indian Journal of Endocrinology and Metabolism Indian Journal of Endocrinology and Metabolism, Vol 16, Iss 7, Pp 79-82 (2012) |
| ISSN: | 2230-9500 2230-8210 |
| Popis: | Aims and Objectives: To estimate serum vitamin B12 levels in type 1 diabetes and to evaluate the influence of duration of diabetes, diabetic control, and age on B 12 levels. Importance of Study: Vitamin B12 deficiency is known to be associated with autoimmune disorders. However, currently there is very limited and controversial data regarding the prevalence of B12 deficiency in type 1 diabetes in South Indian population. If our study demonstrates the presence of low serum B12 levels in type1 diabetes in our population, a recommendation for regular screening and supplementation of vitamin B12 could be considered in these patients. Materials and Methods: This was a cross- sectional study. Ninety type 1 diabetic patients (44 males and 46 females) were randomly selected based on inclusion/ exclusion criteria from the diabetes registry at Bangalore Diabetes Centre. Serum vitamin B12 level and parameters for diabetic controls were estimated using fully automated methods. All statistical analysis was carried out using SPSS version 16. Results: The study showed that 45.5% of the diabetics had low B12 using the manufacturer's cut - off of 180 pg/mL and 54% had low B12 using the published cut - off of 148 pmol/l (200pg/mL). There was no significant difference in B12 levels between males and females (mean difference = - 14.3: P > 0.05). The study did not demonstrate any significant correlation between vitamin B12 levels and age, duration of diabetes, and diabetes control (the r values being - 0.18, - 0.11, and - 0.08 respectively and the P -value > 0.05). Conclusion: Results of our study shows the presence of low serum B12 levels in type 1 diabetics. These findings merits further research on a larger population to investigate into the cause of deficiency and the benefit of B12 supplementation in these patients. |
| Databáze: | OpenAIRE |
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