A novel multifunctional electrochemical platform for simultaneous detection, elimination, and inactivation of pathogenic bacteria based on the Vancomycin-functionalised AgNPs/3D-ZnO nanorod arrays
Autor: | Yi Wang, Dun Zhang, Zhiqing Yang |
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Rok vydání: | 2017 |
Předmět: |
Staphylococcus aureus
Silver Biomedical Engineering Biophysics Nanoparticle Metal Nanoparticles Nanotechnology 02 engineering and technology Biosensing Techniques 010402 general chemistry Electrochemistry medicine.disease_cause 01 natural sciences Vancomycin medicine Detection limit Nanotubes biology Chemistry Pathogenic bacteria General Medicine 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences Anti-Bacterial Agents Nanorod Zinc Oxide 0210 nano-technology Antibacterial activity Bacteria Biotechnology medicine.drug |
Zdroj: | Biosensorsbioelectronics. 98 |
ISSN: | 1873-4235 |
Popis: | A novel fast, sensitive, and specific multifunctional electrochemical platform has been proposed for simultaneous detection, elimination, and inactivation of pathogenic bacteria for the first time. The platform is constituted with three-dimensional ZnO nanorod arrays (3D-ZnO) decorated with sliver nanoparticles (AgNPs) and functionalized with vancomycin (Van). Based on the specific recognition of Van for Gram-positive bacteria, the fabricated electrochemical platform has presented high detection sensitivity to Staphylococcus aureus with a low detection limit of 330cfu/mL and adaptable bacterial-elimination efficiency (50%) at low concentrations (1000-2000cfu/mL). Moreover, the platform has shown high antibacterial activity (99.99%) arising from the synergistic germicidal effect of the composited antibacterial AgNPs and Van units. The current work could provide new strategies to construct advanced platforms for simultaneous detection, elimination, and inactivation of various pathogenic bacteria. |
Databáze: | OpenAIRE |
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