| Autor: |
Hiroshi Haeno, Christine A. Iacobuzio-Donahue, Joseph M. Herman, Lauren M. Rosati, Subhajyoti De, Minoru Oshima, Atsushi Niida, Akira Nakamura, Shinichi Yachida, Kimiyo N. Yamamoto |
| Rok vydání: |
2023 |
| Popis: |
'Supplementary Figures. Fig. S1. Immunohistochemical labeling of CDKN2A, TP53, and SMAD4 from PDAC patients in Japan cohort. Fig. S2. Study design. Fig. S3. The combination of gene alterations in Japan cohort. Fig. S4. CTx improves survival outcomes. Fig. S5. Effects of treatments and immunosuppression on OS in cases with resectable and unresectable diseases. Fig. S6. Effects of treatments and immunosuppression on OS in cases with one, two, and more than two genetic alterations. Fig. S7. Effects of treatments and immunosuppression on OS in cases with oligometastatic (PToligo) and widely metastatic diseases (PTwidely). Fig. S8. Effects of treatments and immunosuppression on OS in cases in T1 and other stages. Fig. S9. Prediction of future progression patterns - PToligo or PTwidely by the number of primary, ALTkras, and ALTmulti cells. Fig. S10. Prediction of future progression patterns - PToligo or PTwidely by the number of ALTtwo cells. Fig. S11. Beneficial effect of adjuvant CRTx on OS in ALT-two throughout the size range at diagnosis. Fig. S12. Beneficial effect of adjuvant CRTx on OS in all cases diagnosed at less than 1-cm in diameter. Fig. S13. Beneficial effect of neoadjuvant CRTx on OS. Fig. S14. Beneficial effect of salvage therapy to isolated recurrence on OS in ALT-two throughout the size range at diagnosis. Fig. S15. Beneficial effect of salvage therapy on OS in all cases diagnosed at less than 1-cm in diameter. Fig. S16. The feasibility of our model validated by clinical data from literatures. Fig. S17. The impact of threshold of ALTtwo cells on selecting potential responders to adjuvant CRTx. Fig. S18. The impact of threshold of ALTtwo cells on selecting potential responders to surgical intervention to the initial recurrence. Fig. S19. The impact of threshold of ALTtwo cells on selecting potential responders to salvage CRTx to the initial recurrence.' |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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