Diabetes Medication Use and Blood Lactate Level among Participants with Type 2 Diabetes: The Atherosclerosis Risk in Communities Carotid MRI Study
| Autor: | Maria Inês Schmidt, Morgana Mongraw-Chaffin, Brad C. Astor, Stephen O. Crawford, Kunihiro Matsushita, J. H Young, Ron C. Hoogeveen, Christie M. Ballantyne, Josef Coresh, Frederick L. Brancati |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male Anatomy and Physiology Mitochondrial Diseases Aterosclerose Epidemiology medicine.medical_treatment lcsh:Medicine Type 2 diabetes 030204 cardiovascular system & hematology Cohort Studies Diabetes mellitus Endocrinology 0302 clinical medicine Risk Factors Blood plasma Insulin Medicine Thiazolidinedione lcsh:Science Ácido láctico Aged 80 and over Multidisciplinary Middle Aged Metformin 3. Good health Female Research Article medicine.drug medicine.medical_specialty medicine.drug_class Endocrine System 030209 endocrinology & metabolism Diabetes Complications 03 medical and health sciences Insulin resistance Internal medicine Humans Hypoglycemic Agents Lactic Acid Aged Clinical Genetics Diabetic Endocrinology Glycated Hemoglobin Endocrine Physiology business.industry lcsh:R Diabetes Mellitus Type 2 Atherosclerosis medicine.disease Survey Methods Cross-Sectional Studies Diabetes Mellitus Type 2 Metabolic Disorders lcsh:Q Thiazolidinediones Preparações farmacêuticas Physiological Processes Energy Metabolism business Body mass index |
| Zdroj: | PLoS ONE PLoS ONE, Vol 7, Iss 12, p e51237 (2012) Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0051237 |
| Popis: | Background The objective of this study is to compare lactate levels between users and non-users of diabetes medications under the hypothesis that the level of lactate is a marker of oxidative capacity. Methods The cross-sectional data of 493 participants aged 61–84 with type 2 diabetes who participated in the Atherosclerosis Risk in Communities Carotid MRI study were analyzed using survey weighted linear regression. Results Median plasma lactate level was 8.58 (95% CI: 8.23, 8.87) mg/dl. Comparing users of diabetic medications with non-users, thiazolidinedione use was significantly associated with lower lactate level (7.57 (6.95–8.25) mg/dL vs. 8.78 (8.43–9.14) mg/dL), metformin use with a slightly higher lactate level (9.02 (8.51–9.58) mg/dL vs. 8.36 (7.96–8.77) mg/dL), and sulfonylurea and insulin use were not associated with lactate level. After adjustment for demographic and lifestyle factors, the plasma lactate level for thiazolidinedione users was 15.78% lower than that for non-users (p |
| Databáze: | OpenAIRE |
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