Functional Magnetic Resonance Imaging in the Final Stage of Creutzfeldt-Jakob Disease
| Autor: | Eugen Trinka, Stefan Golaszewski, Martin Kronbichler, Kerstin Schwenker, Frank Rattay, Raffaele Nardone, Vanessa N. Frey, Larissa Hauer, Bettina Wutzl, Johann Sellner, Axel F Unterrainer, Cristina Florea |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cerebellum
Clinical Biochemistry Central nervous system Posterior parietal cortex Case Report coma Disease 03 medical and health sciences 0302 clinical medicine Degenerative disease 030202 anesthesiology medicine sensorimotor cortex Coma lcsh:R5-920 medicine.diagnostic_test business.industry Unconsciousness vibration paradigm medicine.disease apallic syndrome functional magnetic resonance imaging Creutzfeldt-Jakob disease medicine.anatomical_structure alinetic mutism medicine.symptom Functional magnetic resonance imaging business lcsh:Medicine (General) Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Diagnostics Diagnostics, Vol 10, Iss 309, p 309 (2020) |
| ISSN: | 2075-4418 |
| Popis: | Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare fatal degenerative disease of the central nervous system. The clinical course is characterized by rapid progression of neurological and neuromuscular symptoms. The late stage with loss of consciousness is not well characterized. We report a 62-year-old male patient with sCJD with the clinical picture of a vegetative state/apallic syndrome, in whom we studied cortical responses using a vibration paradigm. The functional magnetic resonance imaging (fMRI) investigation demonstrated a clear response within the sensorimotor cortex, the cerebellum, the parietal cortex, the insular, and frontal inferior region. The finding of persistent cortical activity on fMRI in a patient with CJD in a state of unconsciousness has implications for the clinical management and for ethical considerations. |
| Databáze: | OpenAIRE |
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