Antispasmodic Activity of Fractions and Cynaropicrin from Cynara scolymus on Guinea-Pig Ileum
| Autor: | Rosendo A. Yunes, Fernanda Emendörfer, Fernanda Bellato, Franco Delle Monache, Fabiane Emendörfer, Valdir Cechinel-Filho, Alcı́bia M Cardozo, Vânia Floriani Noldin |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Stereochemistry Guinea Pigs Pharmaceutical Science Ileum In Vitro Techniques Sesquiterpene lactone Lactones chemistry.chemical_compound Cynara scolymus medicine Animals Potency Pharmacology chemistry.chemical_classification Papaverine Dose-Response Relationship Drug Traditional medicine Plant Extracts Parasympatholytics General Medicine Cynaropicrin Antispasmodic Agent Plant Leaves medicine.anatomical_structure chemistry Female Antispasmodic Sesquiterpenes medicine.drug |
| Zdroj: | Biological and Pharmaceutical Bulletin. 28:902-904 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.28.902 |
| Popis: | This study describes the antispasmodic activity of some fractions and cynaropicrin, a sesquiterpene lactone from Cynara scolymus, cultivated in Brazil, against guinea-pig ileum contracted by acetylcholine. The dichloromethane fraction showed the most promising biological effects, with an IC(50) of 0.93 (0.49-1.77) mg/ml. Its main active component, the sesquiterpene lactone cynaropicrin, exhibited potent activity, with IC(50) of 0.065 (0.049-0.086) mg/ml, being about 14-fold more active than dichloromethane fraction and having similar potency to that of papaverine, a well-known antispasmodic agent. The results confirm the popular use of artichoke for the treatment of gastrointestinal disturbances, and encourage new studies on this compound, in order to obtain new antispasmodic agents. |
| Databáze: | OpenAIRE |
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