A phase II study of neoadjuvant docetaxel plus doxorubicin (KBCS-01) in stage II, III breast cancer
| Autor: | Eilsung Chang, Sehwan Han, Sook-Hyun Lim, Sung Soo Kang, Woo-Chul Noh, Sung-Bae Kim, Nam-Sun Paik, Hee-Sook Park, Jeryong Kim |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Time Factors medicine.medical_treatment Phases of clinical research Breast Neoplasms Docetaxel Neutropenia Breast cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Mucositis Humans Neoadjuvant therapy Aged Chemotherapy business.industry Middle Aged medicine.disease Combined Modality Therapy Neoadjuvant Therapy Surgery Treatment Outcome Doxorubicin Female Taxoids business Febrile neutropenia medicine.drug |
| Zdroj: | Breast cancer research and treatment. 98(1) |
| ISSN: | 0167-6806 |
| Popis: | This multicenter phase II study was conducted to evaluate the response and safety of a combination of docetaxel plus doxorubicin as neoadjuvant therapy for stage II, III breast cancer. Patients with stage II or III breast cancer underwent three cycles of neoadjuvant chemotherapy with doxorubicin 50 mg/m2 and docetaxel 75 mg/m2 every 3 weeks followed by curative surgery. Prophylactic GCSF was not used. Ninety patients were enrolled in the study and 86 were evaluable for efficacy. The median age was 43 years (range, 30–69). The mean relative dose intensity was 0.98 for docetaxel and 0.98 for doxorubicin. Breast-conserving surgery was performed in 12 (13.7%) patients. The clinical overall response rate was 86% and pathologic complete response was 10.5%. Grade 3/4 neutropenia was observed in 26% of total 258 cycles and febrile neutropenia was observed in 15.8%. Pneumonia was observed in one patient and grade 3 mucositis was observed in three patients. Docetaxel and doxorubicin was an effective and well-tolerated neoadjuvant chemotherapy for stage II and III breast cancer. Clinical benefit of this treatment will be confirmed by survival data with long term follow up. |
| Databáze: | OpenAIRE |
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