Constituents of Hypericum laricifolium and Their Cyclooxygenase (COX) Enzyme Activities
| Autor: | Kurt B G Torssell, Lars Bohlin, Therese Ringbom, Hesharn Rushdey El-Seedi |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Flavonoid
Ferulic acid chemistry.chemical_compound Drug Discovery Caffeic acid Animals Organic chemistry Phenols Enzyme Inhibitors Benzoic acid chemistry.chemical_classification Sheep Stigmasterol Plant Extracts General Chemistry General Medicine Shikimic acid Isoenzymes chemistry Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Cyclooxygenase 1 Cattle Plant Structures Quercetin Hypericum |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 51:1439-1440 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate (1a), nonacosanyl caffeate (1b). In addition, stigmasterol, beta-sitosterol, 3-epi-betulinic acid (2), caffeic acid (3), ferulic acid, docosanol, p-hydroxybenzoic acid, 3,4-dimethoxy benzoic acid, quercetin (4), quercetin-3-O-galactoside (5), quercetin-3-O-rutinoside (6), quercetin-3-O-rhamnoside (7), quercetin-3-O-glucuronide (8) and shikimic acid were also isolated. The structures were determined by 1D- and 2D-NMR, mass spectrometry, and chemical transformations. The anti-inflammatory effects of the isolated compounds were discussed briefly. |
| Databáze: | OpenAIRE |
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