The prevalence of maternal hypothyroidism in first trimester screening from 11 to 14 weeks of gestation
Autor: | Dagmar Langova, Tomáš Šálek, Ishraq Dhaifalah, Jana Havalova |
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Rok vydání: | 2018 |
Předmět: |
Adult
endocrine system medicine.medical_specialty endocrine system diseases lcsh:Medicine Thyrotropin 030204 cardiovascular system & hematology Thyroid Gland Disorder Iodide Peroxidase General Biochemistry Genetics and Molecular Biology Antibodies 03 medical and health sciences 0302 clinical medicine Maternal hypothyroidism gestation Thyroid-stimulating hormone Hypothyroidism Pregnancy Medicine Humans thyroid disease Subclinical infection Retrospective Studies Immunoassay business.industry Obstetrics Thyroid disease lcsh:R Thyroid medicine.disease Pregnancy Complications Pregnancy Trimester First Thyroxine medicine.anatomical_structure 030220 oncology & carcinogenesis Pregnancy Twin Gestation Female business hormones hormone substitutes and hormone antagonists |
Zdroj: | Biomedical Papers, Vol 163, Iss 3, Pp 265-268 (2019) |
ISSN: | 1804-7521 |
Popis: | Aim: The aim of this study was to determine the prevalence of maternal hypothyroidism in the first trimester from 11 to 14 weeks of gestation according to the American Thyroid Association (ATA) guidelines from 2017 and to compare the rates for singleton and twin pregnancies. Methods: A total of 4965 consecutive Caucasian singleton pregnancies and 109 Caucasian twin pregnancies were included in the investigation. Patients with a history of thyroid gland disorder were excluded. Subclinical maternal hypothyroidism was defined as a thyroid stimulating hormone (TSH) concentration above the 97.5th percentile and free thyroxine (fT4) within the range of a reference population of women at 11-14 weeks of gestation. Overt maternal hypothyroidism was defined as a TSH concentration above the 97.5th percentile and an fT4 below the 2.5th percentile of the reference population.TSH, fT4, and anti thyroid peroxidase antibody (TPOAb) were measured by immunochemiluminescent assays on an 16200 Abbott Architect analyzer. Results: The prevalence of hypothyroidism for twin pregnancies was no higher than that for singleton pregnancies; 6.42% (7/109) vs. 5.32% (264/4965), respectively; P=0.61. All twin pregnancies were subclinical. Singleton hypothyroid pregnancies included 4.91% (244 cases) of subclinical and 0.41% (20 cases) of overt hypothyroidism. The prevalence of TPOAb positive hypothyroid women for twin pregnancies and singleton pregnancies was 71% (5/7) vs. 52% (137/264 cases), respectively but the differences were not statistically significant; P=0.31. Conclusion: Each first trimester screening center should establish its TSH and fT4 reference ranges. Our center had higher upper reference limits of TSH than that of the universally fixed limit of 2.5 mU/L, which led to a lower measured prevalence of maternal hypothyroidism. A large number of hypothyroid women were TPOAb positive. |
Databáze: | OpenAIRE |
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