Medical treatment of myocardial ischemia in coronary artery disease: effect of drug regime and irregular dosing in the CAPE II trial
| Autor: | Sarah T Young, Jean-Marie R. Detry, Jan Bultas, John E. Deanfield, Claudia Brennan, Eric Thaulow, Paul R. Lichtlen, Philippe Sellier, Bruce Beckerman |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Combination therapy Adrenergic beta-Antagonists Ischemia Myocardial Ischemia Coronary Disease Drug Administration Schedule Coronary artery disease Diltiazem Electrocardiography Double-Blind Method medicine Isosorbide mononitrate Humans Amlodipine Aged Aged 80 and over business.industry Cardiovascular Agents Middle Aged medicine.disease Atenolol Calcium Channel Blockers Anesthesia Ambulatory Exercise Test Drug Therapy Combination Female Isosorbide Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of the American College of Cardiology. 40(5) |
| ISSN: | 0735-1097 |
| Popis: | Objectives The Circadian Anti-ischemia Program in Europe (CAPE II) compared the efficacy of amlodipine and diltiazem (Adizem XL) and the combination of amlodipine/atenolol and diltiazem (Adizem XL)/isosorbide 5-mononitrate on exercise and ambulatory myocardial ischemia during regular therapy and after omission of medication. Background The optimal medical therapy for ischemia suppression and the impact of irregular dosing using agents with different pharmacologic properties has not been established in patients with coronary disease. Methods Patients with ≥4 ischemic episodes or ≥20 min of ST segment depression on 72-h electrocardiogram were randomized to amlodipine 10 mg once daily or diltiazem (Adizem XL) 300 mg once daily in a 14-week double-blind randomized multicountry study. In the second phase, atenolol 100 mg was added to amlodipine and isosorbide 5-mononitrate 100 mg to diltiazem (Adizem XL). Ambulatory monitoring (72 h) and exercise testing were repeated after both phases, on treatment and after a 24-h drug-free interval. Results Both monotherapy with amlodipine and diltiazem (Adizem XL) were effective on symptoms and ambulatory and exercise ischemia. Combination therapy reduced ischemia further, with amlodipine/atenolol superior to diltiazem (Adizem XL)/isosorbide 5-mononitrate. Amlodipine/atenolol was significantly superior during the drug-free interval with maintenance of ischemia reduction. Conclusions Amlodipine, with its intrinsically long half-life alone or together with beta-blocker, is likely to produce superior ischemia reduction in clinical practice when patients frequently forget to take medication or dose irregularly. |
| Databáze: | OpenAIRE |
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