The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication
| Autor: | Zvi Ackerman, Ora Paltiel, Lior H Katz, Michal Shauly-Aharonov, Asher Shafrir, Yishai Pickman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Vitamin medicine.medical_specialty Helicobacter pylori eradication Population lcsh:TX341-641 vitamin D macromolecular substances Gastroenterology Helicobacter pylori infection 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Israel education Serum vitamin education.field_of_study Nutrition and Dietetics biology business.industry 25-hydroxyvitamin D2 Helicobacter pylori biology.organism_classification bacterial infections and mycoses 030104 developmental biology chemistry Health maintenance Increased vitamin D 030211 gastroenterology & hepatology Electronic database business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Volume 13 Issue 1 Nutrients, Vol 13, Iss 278, p 278 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13010278 |
| Popis: | Background: The success of Helicobacter pylori (H. pylori) eradication depends on several host and treatment factors. Serum vitamin D levels may be associated with H. pylori infection and eradication rates. We investigated the association between vitamin D and H. pylori infection and eradication, using a large electronic database based on medical records from a population-based health maintenance organization. Methods: Data regarding adults who underwent H. pylori testing and had vitamin D measurements within one month of H. pylori testing were collected. H. pylori infection was ascertained using urea breath or stool antigen tests. A negative H. pylori test following a positive result implied eradication. Multivariate regression models were constructed to assess associations between H. pylori infection, eradication, and vitamin D. Results: Among 150,483 members who underwent H. pylori testing from 2009 to 2018, 27,077 (18%) had vitamin D measurements. Vitamin D levels were inversely associated with H. pylori infection, p < 0.001. The odds of a positive H. pylori test were 31% higher among patients with vitamin D levels < 20 ng/mL, compared with those with levels &ge 20 ng/mL (OR 1.31, 99% CI 1.22&ndash 1.4, p < 0.001). Purchase of vitamin D supplements was associated with a negative subsequent H. pylori test (p < 0.001). Mean vitamin D levels were moderately higher in those with successful vs. failed H. pylori eradication (19.34 ± 9.55 vs. 18.64 ± 9.61, p < 0.001). Conclusions: Vitamin D levels are associated with H. pylori infection. Increased vitamin D levels are associated with successful H. pylori eradication. Vitamin D may have a role in H. pylori eradication. |
| Databáze: | OpenAIRE |
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