Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity
| Autor: | Chun-Xue Yu, Pan-Jie Su, Dong-Qing Fei, Yi-Fan Yu, Feng-Ming Qi, Zhan-Xin Zhang, Zhi Dejuan, Ye Zhao, Bing Li, Ru-Yue Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Euphorbia
Anti alzheimer Dose-Response Relationship Drug Molecular Structure biology Chemistry Stereochemistry Organic Chemistry Antiprotozoal Agents Absolute configuration Carbon skeleton biology.organism_classification Biochemistry Triterpenes Structure-Activity Relationship Triterpenoid Parasitic Sensitivity Tests Alzheimer Disease Animals Structure–activity relationship Physical and Theoretical Chemistry Caenorhabditis elegans Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Organic & Biomolecular Chemistry. 18:76-80 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c9ob02334h |
| Popis: | Eupulcherol A (1), a novel triterpenoid with an unprecedented carbon skeleton, was isolated from Euphorbia pulcherrima. Its structure was determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR, and the absolute configuration was defined by single crystal X-ray diffraction analysis. Biological studies showed that compound 1 possessed anti-Alzheimer's disease (AD) bioactivity, which could delay paralysis of transgenic AD Caenorhabditis elegans. A plausible biogenetic pathway for eupulcherol A (1) was also proposed. |
| Databáze: | OpenAIRE |
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