Pleiotropic Effects of DCDC2 and DYX1C1 Genes on Language and Mathematics Traits in Nuclear Families of Developmental Dyslexia
| Autor: | Sara Mascheretti, Roberto Giorda, Claudio Lazazzera, Cecilia Marino, Catia Rigoletto, Massimo Molteni, Francesca Cattaneo, Marianna Rusconi, Jeffrey R. Gruen, Valentina Riva |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Proband
Genetic Markers Male Linkage disequilibrium Genotype Genome-wide association study Biology Neuropsychological Tests Article Linkage Disequilibrium Nuclear Family Cohort Studies Dyslexia Pleiotropy DCDC2 Genetics medicine Humans Genetic Predisposition to Disease Language Development Disorders Child Nuclear family Genetics (clinical) Ecology Evolution Behavior and Systematics Learning Disabilities Genetic Pleiotropy Transmission disequilibrium test medicine.disease Phenotype Child Preschool Female Mathematics Genome-Wide Association Study |
| Popis: | Converging evidence indicates that developmental problems in oral language and mathematics can predate or co-occur with developmental dyslexia (DD). Substantial genetic correlations have been found between language, mathematics and reading traits, independent of the method of sampling. We tested for association of variants of two DD susceptibility genes, DCDC2 and DYX1C1, in nuclear families ascertained through a proband with DD using concurrent measurements of language and mathematics in both probands and siblings by the Quantitative Transmission Disequilibrium Test. Evidence for significant associations was found between DCDC2 and ‘Numerical Facts’ (p value = 0.02, with 85 informative families, genetic effect = 0.57) and between ‘Mental Calculation’ and DYX1C1 markers -3GA (p value = 0.05, with 40 informative families, genetic effect = −0.67) and 1249GT (p value = 0.02, with 49 informative families, genetic effect = −0.65). No statistically significant associations were found between DCDC2 or DYX1C1 and language phenotypes. Both DCDC2 and DYX1C1 DD susceptibility genes appear to have a pleiotropic role on mathematics but not language phenotypes. |
| Databáze: | OpenAIRE |
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