Influence of renal failure on cytochrome P 450 activity in hypertensive patients using a 'cocktail' of antipyrine and nifedipine
| Autor: | Vera Lucia Lanchote, Silvia Regina Cavani Jorge Santos, W. C. Ping |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Drug endocrine system medicine.medical_specialty Nifedipine media_common.quotation_subject Pharmacology toxicology Cytochrome P-450 Enzyme System Pharmacokinetics Internal medicine Humans Medicine Pharmacology (medical) Antihypertensive Agents Biotransformation Chromatography High Pressure Liquid media_common Pharmacology biology business.industry Cytochrome P450 activity Anti-Inflammatory Agents Non-Steroidal Cytochrome P450 General Medicine Metabolism Middle Aged Drug Combinations Endocrinology Hypertension biology.protein Kidney Failure Chronic Female business Antipyrine Half-Life medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 50:83-89 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/s002280050073 |
| Popis: | Two substrates were coadministered in a "cocktail" approach to evaluate the contribution of renal failure to drug oxidation.Nineteen hypertensive patients, nine of them with chronic renal failure (CLCR 38.9 vs 102.3 ml.min-1 1.73 m-2), were investigated after peroral administration of a combination of antipyrine (500 mg, in capsules) and nifedipine (10 mg, in Oxcord capsules) in the morning after an overnight fast.This "cocktail" approach made it possible to characterize in vivo the activities of different forms of cytochrome P450 in a single-study protocol using the total clearance of nifedipine and clearance for production of 3-hydroxymethylantipyrine (HMA), 4-hydroxyantipyrine (OHA) and norantipyrine (NORA). With this "cocktail" approach (antipyrine plus nifedipine), we can suggest a selective effect on the activities of cytochrome P450 forms associated with the formation of dehydronifedipine (P450 III A4) and of NORA in patients with mild renal failure under long-term antihypertensive therapy. |
| Databáze: | OpenAIRE |
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