HPV replication in experimental models: effects of interferon
| Autor: | J D Gangemi, Michael G. Angell, L Pirisi, John W. Kreider |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Keratinocytes
medicine.medical_treatment Alpha interferon Cervix Uteri Biology Virus Mice Plantar warts Interferon Virology medicine Animals Humans Papillomaviridae Interferon alfa Cells Cultured Pharmacology Clinical Trials as Topic Papillomavirus Infections HPV infection virus diseases Immunotherapy medicine.disease Transplantation Disease Models Animal Tumor Virus Infections Immunology Female Interferons Rabbits medicine.drug |
| Zdroj: | Antiviral research. 24(2-3) |
| ISSN: | 0166-3542 |
| Popis: | Preclinical evaluation of the effectiveness of interferon (IFN) therapy on human papillomaviruses (HPV) has been hampered by the inability to propagate these viruses in cell culture. Nonetheless, interferon is used extensively in the treatment of HPV infections. Alpha interferons in particular have found a place in the treatment of anogenital disease, plantar warts, and laryngeal papillomas. While their is significant clinical evidence to suggest that interferon is useful in therapy of disease, the cellular mechanism(s) (i.e., antiviral, antiproliferative, immunomodulatory) by which IFN is able to control HPV-induced pathology is not well understood. This review focuses on experimental animal and cell culture models which are currently being used to help identify the antiviral, antiproliferative and immunomodulatory effects of IFN on HPV infection. |
| Databáze: | OpenAIRE |
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