Development of new levodopa treatment strategies in Parkinson’s disease—from bedside to bench to bedside
| Autor: | Dag Nyholm, Sten-Magnus Aquilonius |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Central Nervous System
medicine.medical_specialty Levodopa Parkinson's disease lcsh:Medicine Review Article Pharmacology 030226 pharmacology & pharmacy History 21st Century 03 medical and health sciences Preclinical research 0302 clinical medicine Drug Delivery Systems Medicine media_common.cataloged_instance Animals Humans European Union European union levodopa Intensive care medicine Drug Approval media_common Randomized Controlled Trials as Topic intestinal gel business.industry microtablets lcsh:R Carbidopa Parkinson Disease General Medicine History 20th Century medicine.disease drug development Bench to bedside Drug Combinations Drug development Drug Design Parkinson’s disease Treatment strategy business Gels 030217 neurology & neurosurgery medicine.drug Tablets |
| Zdroj: | Upsala Journal of Medical Sciences, Vol 122, Iss 2, Pp 71-77 (2017) Upsala Journal of Medical Sciences |
| ISSN: | 2000-1967 0300-9734 |
| Popis: | This review will illustrate the process of moving from an idea through preclinical research and Galenic developments into clinical investigations and finally to approval by regulatory agencies within the European Union. The two new treatment strategies described, levodopa/carbidopa intestinal gel and levodopa/carbidopa microtablets, for advanced Parkinson’s disease, have been developed in collaborative research within departments at Uppsala University. With this historical approach, reference priority is given to reports considered to be of special importance for this more than two decades long process ‘from bedside to bench to bedside’. |
| Databáze: | OpenAIRE |
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