Glioma stem cells and their roles within the hypoxic tumor microenvironment
| Autor: | Joshua D. Bernstock, Anita B. Hjelmeland, Gregory K. Friedman, G. Yancey Gillespie, Nathaniel H. Boyd, Tina Etminan, Anh Nhat Tran, Amber Jones |
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| Rok vydání: | 2021 |
| Předmět: |
cancer stem cells
0301 basic medicine Angiogenesis Medicine (miscellaneous) Review Biology 03 medical and health sciences 0302 clinical medicine Cancer stem cell glioma Glioma medicine Animals Humans tumor microenvironment Pharmacology Toxicology and Pharmaceutics (miscellaneous) Tumor microenvironment Neovascularization Pathologic acidic stress Brain Neoplasms hypoxia Hypoxia (medical) medicine.disease Phenotype 030104 developmental biology Tumor progression Neoplastic Stem Cells Cancer research medicine.symptom Stem cell 030217 neurology & neurosurgery |
| Zdroj: | Theranostics |
| ISSN: | 1838-7640 |
| DOI: | 10.7150/thno.41692 |
| Popis: | Tumor microenvironments are the result of cellular alterations in cancer that support unrestricted growth and proliferation and result in further modifications in cell behavior, which are critical for tumor progression. Angiogenesis and therapeutic resistance are known to be modulated by hypoxia and other tumor microenvironments, such as acidic stress, both of which are core features of the glioblastoma microenvironment. Hypoxia has also been shown to promote a stem-like state in both non-neoplastic and tumor cells. In glial tumors, glioma stem cells (GSCs) are central in tumor growth, angiogenesis, and therapeutic resistance, and further investigation of the interplay between tumor microenvironments and GSCs is critical to the search for better treatment options for glioblastoma. Accordingly, we summarize the impact of hypoxia and acidic stress on GSC signaling and biologic phenotypes, and potential methods to inhibit these pathways. |
| Databáze: | OpenAIRE |
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