Codon 54 polymorphism of the fatty acid binding protein (FABP) 2 gene is associated with increased cardiovascular risk in the dyslipidemic diabetic participants of the veterans affairs HDL intervention trial (VA-HIT)
| Autor: | Sander J. Robins, Angeliki Georgopoulos, Hanna E. Bloomfield, Dorothea Collins, Margaret E. Brousseau, Ernest J. Schaefer, Jose M. Ordovas, John J. O’Connor |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Myocardial Infarction Fatty Acid-Binding Proteins Gastroenterology Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus Clinical endpoint medicine Humans Genetic Predisposition to Disease Cumulative incidence Myocardial infarction Codon Veterans Affairs Aged Dyslipidemias Hypolipidemic Agents Polymorphism Genetic business.industry Proportional hazards model Incidence Hazard ratio Middle Aged medicine.disease United States Stroke United States Department of Veterans Affairs Endocrinology Gemfibrozil Cardiology and Cardiovascular Medicine business Dyslipidemia |
| Zdroj: | Atherosclerosis. 194:169-174 |
| ISSN: | 0021-9150 |
| Popis: | The threonine (Thr) for alanine (Ala) codon 54 polymorphism of the fatty acid binding protein (FABP) 2 gene, when compared to the wild type, is associated with dyslipidemia. Since dyslipidemia is common in diabetes and is associated with increased cardiovascular risk, we tested the hypothesis that Thr-54 is associated with increased cardiovascular risk in patients with diabetes. The secondary prevention veterans affairs HDL intervention trial (VA-HIT) was carried out in patients with dyslipidemia. The DNA of trial participants (n=776) was screened for the Thr-54 polymorphism and cardiovascular endpoints were monitored. The polymorphism was detected in 370 (47.7%). For first occurrence of the primary endpoint [myocardial infarction (MI) or coronary heart disease (CHD) death] the hazard ratio (HR) and confidence intervals (Cox proportional hazards model) was 2.5 (1.2, 5.3) p=.02 in diabetic carriers of Thr-54 versus carriers without diabetes or fasting glucose >7 mmol/L. For the expanded endpoint (stroke, MI or CHD death), the corresponding HR was 3.0 (1.4, 5.4) p=.0003 and for the stroke alone the corresponding HR was 3.5 (1.4-8.9) p=.01. The higher cumulative incidence of the expanded endpoint in diabetic participants carrying the FABP2 polymorphism versus non-diabetic carriers was consistently present throughout the 5 years of the study (p=.0002). We conclude that based on the VA-HIT data, the Thr-54 polymorphism of the FABP2 gene is associated with a 2-3.5-fold increase in cardiovascular risk in dyslipidemic men with diabetes compared to their non-diabetic counterparts. |
| Databáze: | OpenAIRE |
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