GABAergic mediation of hippocampal theta rhythm induced by stimulation of the vagal nerve
| Autor: | Adam Broncel, P Klos-Wojtczak, Jan Konopacki, Renata Bocian |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Baclofen Vagus Nerve Stimulation GABAB receptor Hippocampal formation Bicuculline Hippocampus GABA Antagonists 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals GABAergic Neurons Rats Wistar Theta Rhythm GABA Agonists gamma-Aminobutyric Acid Neurons Muscimol GABAA receptor General Neuroscience Vagus Nerve Receptors GABA-A Rats 030104 developmental biology Receptors GABA-B nervous system chemistry Saclofen GABAergic Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brain Research Bulletin. 147:110-123 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2019.02.010 |
| Popis: | The key question to be answered in the present study was whether the medial septal GABAergic receptors are engaged in the pharmacological profile of the hippocampal formation (HPC) theta rhythm induced by vagal nerve stimulation (VNS). It was demonstrated that the medial septal microinfusion of GABAA and GABAB agonists (muscimol and baclofen) resulted in a progressive reduction of the power of VNS-induced theta. The medial septal microinfusion of GABAA and GABAB antagonists (bicuculline and 2-OH saclofen) resulted in the generation of VNS-induced theta with increased power. The effect of the combined medial septal microinfusion of GABAA agonist and antagonist and GABAB agonist and antagonist on VNS-induced theta rhythm was also evaluated: in the presence of GABAA,B antagonists the effect of agonists predominated. In separate experiments, GABAA and GABAB antagonists were administrated in anesthetized rats pretreated with i.v. administration of atropine sulfate. Atropine was found to abolish spontaneous theta and VNS-induced theta examined in the presence of bicuculline or 2-OH saclofen. The present data provide evidence that the medial septal GABAA and GABAB receptors are involved in the central mechanisms responsible for modulation of VNS-induced HPC theta oscillations. Furthermore, the results of the present study also demonstrate that, in fact, both GABAergic and cholinergic involvement is necessary for the appearance of VNS-induced theta. |
| Databáze: | OpenAIRE |
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