Ultrastructural changes in murine liver following HSV infection and stroke
| Autor: | S. L. Rybalko, Natalia Motorna, Rostyslav F. Kaminsky, Tatyana Yu Kvitnitskaya-Ryzhova, Iryna G Strokina, L. M. Sokurenko, Yuri Chaikovsky, Sergey Savosko, Daria B Starosyla |
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| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty viruses Pharmacology toxicology lcsh:Medicine Pharmacy liver Biochemistry 03 medical and health sciences 0302 clinical medicine medicine Molecular Biology Stroke Pharmacology Hsv infection business.industry lcsh:R General Medicine medicine.disease ultrastructure stroke herpes simplex virus type I 030220 oncology & carcinogenesis Murine liver business 030217 neurology & neurosurgery |
| Zdroj: | Current Issues in Pharmacy and Medical Sciences, Vol 31, Iss 1, Pp 10-12 (2018) |
| ISSN: | 2300-6676 2084-980X |
| Popis: | The study of herpetic infection is a topical problem. Although the peculiarities and consequences of acute HSV-I infection in the brain are quite well-studied, little is known about the damage to other organs which are not a source of latent HSV-I infection, the liver in particular. The current study is aimed at determining the ultrastructural changes in murine liver following HSV infection and stroke. Liver samples obtained from four groups of animals were studied: 1) intact mice; 2) mice with stroke; 3) mice infected with HSV-I; 4) mice aflicted with HSV-I and subsequently simulated stroke. The study showed the reproduction of the virus in hepatic endotheliocytes, although no virions were detected in the hepatocytes. Therefore, the described changes were considered the consequences of the infectious process. Pathological changes of hepatocytes consisted of deformation and fragmentation of the nuclei, as well as accumulation of osmiophilic granules, lysosomes and lamellary bodies. Latent HSV-I infection may reactivate in liver after the stroke, potentially causing the complications of the underlying disease. |
| Databáze: | OpenAIRE |
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