Consumption of vitamin B(6) reduces fecal ratio of lithocholic acid to deoxycholic acid, a risk factor for colon cancer, in rats fed a high-fat diet
| Autor: | Sofya Suidasari, Noriyuki Yanaka, Yukako Okazaki, Hiroyuki Tomotake, Norihisa Kato, Ei Sakaguchi, Zaki Utama, Peipei Zhang |
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| Rok vydání: | 2013 |
| Předmět: |
Immunoglobulin A
Male medicine.medical_specialty Lithocholic acid medicine.drug_class Colon Medicine (miscellaneous) Diet High-Fat Bile Acids and Salts Rats Sprague-Dawley chemistry.chemical_compound Feces Immune system Risk Factors Internal medicine medicine Animals Cecum Barrier function Nutrition and Dietetics Bile acid biology Deoxycholic acid Mucin Mucins Dietary Fats Vitamin B 6 Rats Endocrinology chemistry Colonic Neoplasms biology.protein Lithocholic Acid Deoxycholic Acid |
| Zdroj: | Journal of nutritional science and vitaminology. 58(5) |
| ISSN: | 1881-7742 |
| Popis: | To examine the effect of supplemental dietary vitamin B(6) on the colonic luminal environment, growing male rats were fed a high-fat diet containing 1, 7, or 35 mg pyridoxine HCl/kg diet for 6 wk. Food intake and growth were unaffected by the dietary treatment. Supplemental dietary vitamin B(6) significantly reduced the production of a fecal secondary bile acid, lithocholic acid (the most toxic secondary bile acid and a risk factor for colon cancer), and markedly reduced the ratio of lithocholic acid to deoxycholic acid (a less toxic secondary bile acid) in feces (p |
| Databáze: | OpenAIRE |
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