Impact of Occult Hepatitis B Virus Infection on the Outcome of Chronic Hepatitis C
| Autor: | Irene Cacciola, Giovanni Raimondo, Teresa Pollicino, Giovanni Squadrito, Angela Alibrandi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty HBsAg Cirrhosis Carcinoma Hepatocellular Hepatitis C virus medicine.disease_cause Gastroenterology Young Adult Hepatitis B Chronic Internal medicine medicine Humans HBsAg-negative Aged Hepatitis B virus Aged 80 and over Hepatology medicine.diagnostic_test business.industry Coinfection Hepatocellular Carcinoma Occult HBV infection (OBI) Liver Neoplasms Hepatitis C Chronic Middle Aged medicine.disease Prognosis Occult Survival Analysis Treatment Outcome Hepatocellular carcinoma Liver biopsy Immunology Female business Cohort study Follow-Up Studies |
| Popis: | Occult hepatitis B virus infection (OBI) frequently occurs in patients with hepatitis C virus (HCV) related chronic hepatitis (CHC), but the influence of OBI on the CHC outcome is still uncertain. This observational cohort study evaluated the clinical evolution of CHC patients according to their OBI status.From 1991 to 2000, 326 hepatitis B surface antigen negative CHC patients were tested for OBI by the analysis of liver biopsy DNA extracts. A total of 128/326 cases (39.2%) tested OBI positive and 198/326 (60.8%) OBI negative. Ninety-four of 326 patients (37 OBI positive, 57 OBI negative) were followed-up for a median time of 11 years (range 5-19 years). During the follow-up, 79/94 patients underwent anti-HCV treatments and 25 [corrected] achieved a sustained virological response that occurred independently of their OBI statusEighteen patients (13/37 OBI positive, 5/57 OBI negative, p0.01) developed hepatocellular carcinoma (HCC). Among the 76 non-HCC individuals, 15 subjects (8/24 OBI positive, 7/52 OBI negative, p0.05) developed advanced forms of cirrhosis. Eighteen patients died during follow-up and 2 underwent liver transplantation. OBI positive individuals had a cumulative survival rate significantly shorter than OBI negative individuals (p = 0.003). Liver-related deaths were more frequently found in OBI positive than OBI negative patients (12/37 OBI positive vs. 6/57 OBI negative patients respectively, p0.01). Finally, non-response to anti-HCV therapy was significantly associated with lower survival (p = 0.02).Among CHC patients, occult HBV co-infected individuals are a category at high risk of progression toward cirrhosis, HCC development, and lower survival. |
| Databáze: | OpenAIRE |
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