Erythropoiesis-stimulating agent withdrawal and oxidative stress in hemodialysis
| Autor: | Eszter Karg, Sándor Túri, Zsuzsanna Hracskó, Ferenc Papp, Viktória Sümegi, Ibolya Haszon, Ilona Sz Varga, Péter Monostori, Csaba Bereczki, E. Kiss, Z. Kiss, T. Boros |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes medicine.disease_cause Lipid peroxidation Superoxide dismutase Hemoglobins chemistry.chemical_compound Renal Dialysis Internal medicine medicine Humans Darbepoetin alfa Erythropoietin Whole blood Glutathione Disulfide biology Superoxide Dismutase business.industry Anemia General Medicine Glutathione Middle Aged Prognosis Malondialdehyde Recombinant Proteins Surgery Oxidative Stress Endocrinology Withholding Treatment chemistry Nephrology Catalase Hematinics biology.protein Kidney Failure Chronic Female business Oxidative stress Follow-Up Studies medicine.drug |
| Zdroj: | Clinical Nephrology. 71:521-526 |
| ISSN: | 0301-0430 |
| DOI: | 10.5414/cnp71521 |
| Popis: | AIMS Variation of the action of erythropoiesis-stimulating agent (ESA) may modify oxidative stress in hemodialyzed (HD) patients. Our aim was to follow changes of oxidative stress during withdrawal and subsequent resumption of ESA therapy. PATIENTS AND METHODS After a 14-day suspension of epoietin-beta treatment, 11 HD patients received epoietin-beta and 10 patients darbepoietin-alpha. The whole blood oxidized and reduced glutathione (GSSG, GSH) and erythrocyte malondialdehyde (E-MDA) concentrations and the erythrocyte superoxide dismutase (E-SOD) and catalase (E-CAT) activities were determined before the ESA-free interval (baseline) and at Weeks 2, 6, 10 and 14. RESULTS In both groups, the ratios GSSG/ GSH were increased at Weeks 2 and 6 (p < 0.001). The E-MDA levels were elevated (p < 0.01) and the E-SOD activities were decreased (p < 0.001) at Week 6. By Week 14, these markers had returned to the baseline, whereas the GSH (p < 0.001) and E-CAT activity levels (p < 0.001) had increased. CONCLUSIONS An increase in oxidative stress was revealed by the ratio GSSG/GSH directly after the short-term withdrawal of epoietin-b therapy in HD. This new finding may have implications in conditions involving transiently depressed ESA action. For both ESAs, the early phase of readministration was associated with similarly increased oxidative stress, with a subsequent return to the baseline level. |
| Databáze: | OpenAIRE |
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