Modified epidermal growth factor receptor (EGFR)-bearing liposomes (MRBLs) are sensitive to EGF in solution
| Autor: | Albert Wong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
lcsh:Medicine
Benzoates Models Biological Permeability Drug Delivery Systems Epidermal growth factor medicine Animals Humans Epidermal growth factor receptor lcsh:Science Ovum Liposome Multidisciplinary Dactinomycin Epidermal Growth Factor biology Chemistry lcsh:R Cell cycle Cell biology ErbB Receptors Cross-Linking Reagents Biochemistry Permeability (electromagnetism) Liposomes Chemical Biology/Biomimetic Chemistry Phosphatidylcholines biology.protein Biotechnology/Protein Chemistry and Proteomics lcsh:Q Biotechnology/Bioengineering Drug carrier Chickens Dimerization hormones hormone substitutes and hormone antagonists Research Article medicine.drug |
| Zdroj: | PLoS ONE, Vol 4, Iss 10, p e7391 (2009) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Cancers often overexpress EGF and other growth factors to promote cell replication and migration. Previous work has not produced targeted drug carriers sensitive to abnormal amounts of growth factors. This work demonstrates that liposomes bearing EGF receptors covalently crosslinked to p-toluic acid or methyl-PEO(4)-NHS ester (or, in short, MRBLs) exhibit an increased rate of release of encapsulated drug compounds when EGF is present in solution. Furthermore, the modified EGF receptors retain the abilities to form dimers in the presence of EGF and bind specifically to EGF. These results demonstrate that MRBLs are sensitive to EGF in solution and indicate that MRBL-reconstituted modified EGF receptors, in the presence of EGF in solution, form dimers which increase MRBL permeability to encapsulated compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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