Tissue distribution of cynomolgus adeno-associated viruses AAV10, AAV11, and AAVcy.7 in naturally infected monkeys
| Autor: | Seiichiro Mori, Takamasa Takeuchi, Tadahito Kanda, T. Sata, K. Sato, Fumiko Ono, Kazunari Kondo, Yutaka Enomoto |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Lymphoid Tissue viruses Ileum Biology Lymphatic tissues Polymerase Chain Reaction Virus Parvoviridae Infections Medical microbiology Immune system Viral genetics Virology medicine Animals Tissue distribution Phylogeny Sequence Homology Amino Acid Monkey Diseases General Medicine Dependovirus Macaca fascicularis medicine.anatomical_structure Helper virus DNA Viral Capsid Proteins |
| Zdroj: | Archives of Virology. 153:375-380 |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | Adeno-associated virus (AAV) is used in gene-therapy studies, but its tissue distribution is unknown in natural infection. We examined cynomolgus AAVs (previously isolated AAV10 and AAV11 and novel AAVcy.7) for their tissue distribution in 14 cynomolgi by type-specific PCR. We found AAV10, AAV11, and AAVcy.7 in 6, 10, and 14 monkeys, respectively, and two or three types in 11 monkeys, showing that these AAVs are widespread in the monkeys. We detected AAV at a higher level mainly in the lymphatic tissues and ileum, which suggests that AAV may invade the host through Peyer's patches in the ileum and infect immune cells. |
| Databáze: | OpenAIRE |
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