Murine sperm capacitation, oocyte penetration and decondensation following moderate alcohol intake
| Autor: | Melisa Celeste Sanchez, Lucrecia Calvo, Juan Carlos Calvo, Maite Yael Cambiasso, Cristian Marcelo Sobarzo, Elisa Cebral, Camila Galotto, Vanina Andrea Fontana |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Embryology medicine.medical_treatment Acrosome reaction ALCOHOL Fertilization in Vitro Ciencias Biológicas purl.org/becyt/ford/1 [https] Andrology Mice 03 medical and health sciences 0302 clinical medicine Endocrinology Human fertilization Capacitation Animals Medicine purl.org/becyt/ford/1.6 [https] Sperm-Ovum Interactions 030219 obstetrics & reproductive medicine In vitro fertilisation Ethanol Hyperactivation Pronucleus business.industry Acrosome Reaction Biología del Desarrollo Obstetrics and Gynecology SPERM CAPACITATION Cell Biology Sperm 030104 developmental biology Reproductive Medicine OOCYTE PENETRATION Anti-Infective Agents Local Oocytes HEAD DECONDENSATION business Sperm Capacitation CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 1741-7899 1470-1626 |
| Popis: | Male chronic alcohol abuse causes testicular failure and infertility. We analyzed the effects of moderate sub-chronic alcohol intake on sperm morphology, capacitation, fertilization and sperm head decondensation. CF-1 male mice were administered 15% ethanol in drinking water for 15 days; control mice received ethanol-free water. Similar patterns of tyrosine phosphorylation were observed in capacitated spermatozoa of control and treated males. Percentage of hyperactivation (H) and spontaneous (SAR) and progesterone-induced (IAR) acrosome reaction significantly decreased at 120 and 150min of capacitation in treated males compared to controls (H: 14.1±2.5 vs 23.7±2.6, P |
| Databáze: | OpenAIRE |
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