Randomized trial of prongs or mask for nasal continuous positive airway pressure in preterm infants
| Autor: | Eleanor J. Molloy, A Twomey, Emily A Kieran, John F A Murphy, Colm P F O'Donnell |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Infant Premature Diseases law.invention Randomized controlled trial law medicine Intubation Intratracheal Intubation Humans Continuous positive airway pressure Nose Oxygen saturation (medicine) Mechanical ventilation Respiratory distress Continuous Positive Airway Pressure business.industry Infant Newborn Equipment Design Respiration Artificial Surgery medicine.anatomical_structure Anesthesia Pediatrics Perinatology and Child Health Breathing Female business |
| Zdroj: | Pediatrics. 130(5) |
| ISSN: | 1098-4275 |
| Popis: | OBJECTIVE:To determine whether nasal continuous positive airway pressure (NCPAP) given with nasal prongs compared with nasal mask reduces the rate of intubation and mechanical ventilation in preterm infants within 72 hours of starting therapy.METHODS:Infants 0.4 to keep oxygen saturation >88% sustained for 30 minutes; pH 9 kPa [68 mm Hg] on 2 blood gases ≥30 minutes apart) within 72 hours of starting therapy. The groups were treated the same in all other respects. We recorded relevant secondary outcomes and analyzed data by using the intention-to-treat principle.RESULTS:We enrolled 120 infants. Thirty-two of 62 (52%) infants randomly assigned to prongs were intubated within 72 hours, compared with 16/58 (28%) of those randomly assigned to mask (P = .007). There were no statistically significant differences between the groups in any secondary outcomes.CONCLUSIONS:In premature infants, NCPAP was more effective at preventing intubation and ventilation within 72 hours of starting therapy when given via nasal masks compared with nasal prongs. |
| Databáze: | OpenAIRE |
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