A NEW SCREENING METHOD FOR ANTIDIABETICS BASED ON THE INTRAVENOUS GLUCOSE TOLERANCE TEST IN RABBITS
| Autor: | Toshiko Sasaki, Masuo Tobe, Setsuya Takeuchi |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Sodium Blood sugar chemistry.chemical_element Pharmacology Subcutaneous injection Endocrinology Tolbutamide Internal medicine Animals Hypoglycemic Agents Medicine Glucose tolerance test medicine.diagnostic_test business.industry Insulin General Engineering Glucose Tolerance Test Metformin chemistry Regular insulin Rabbits business medicine.drug |
| Zdroj: | Endocrinologia Japonica. 8:247-258 |
| ISSN: | 2185-6370 0013-7219 |
| DOI: | 10.1507/endocrj1954.8.247 |
| Popis: | Effect of some antidiabetics on the blood sugar curve after intravenous injection of glucose was investigated with the rabbits pre-treated with priscoline. Since an action of priscoline was found to make the curve type exponential, configuration of glucose tolerance curve could be determined by two constants, e-k and C in a formula yt=ae-kt+C (y, blood sugar level; t, time; a, initial blood sugar).Influences of antidiabetics, insulin, tolbutamide (N-toluyl-sulfonyl-N'-butylurea), metformin (Dimethylbiguanide) and sodium mesoxalate injected intravenously, were as follows:(1)Examinations after single administrationa) After administration of 0.05u./kg of regular insulin, e-k and C became both smaller than those for control. They were influenced in the similar way by subcutaneous injection of 0.1u./kg. b) After injection of 100mg/kg of tolbutamide, C value decreased significantly without change in e-k value. c) 50mg/kg of metformin gave an increasing effect on both of the two constants.(2) Examinations after repeated administrationsAfter the administrations of 100mg/kg of sodium mesoxalate during 5 or 10 days, e-k became smaller but Clarger.(3) There were not any changes in e-k and I values at ter single administration of 100mg/kg of the mesoxalate, or after the repeated administrations of 0.05u./kg of insulin, 100mg/kg of tolbutamide or 31mg/kg of the mesoxalate.Mechanism of these actions was briefly referred to, and a possibility was discussed to apply this glucose tolerance test to the pharmacological screening method for antidiabetics. |
| Databáze: | OpenAIRE |
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