A 2.5-Year Longitudinal Assessment of Naturalistic Driving in Preclinical Alzheimer’s Disease
| Autor: | Jennifer D. Davis, Monique M. Williams, Brian R. Ott, Beau M. Ances, David K. Warren, Catherine M. Roe, Ganesh Rajasekar, Jessica M Jones, Sarah H. Stout, Ganesh M. Babulal, Denise Head, Tammie L.S. Benzinger |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Automobile Driving medicine.medical_specialty Prodromal Symptoms Disease Article 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Alzheimer Disease Surveys and Questionnaires medicine Humans Aged Aged 80 and over Aggression business.industry General Neuroscience General Medicine Automobile driving Psychiatry and Mental health Clinical Psychology 030104 developmental biology Positron-Emission Tomography Gps data Female Geriatrics and Gerontology Naturalistic driving medicine.symptom Preclinical stage business human activities 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 68:1625-1633 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-181242 |
| Popis: | BACKGROUND: Emerging evidence shows that cognitively normal older adults with preclinical Alzheimer’s disease (AD) make more errors and are more likely to receive a marginal/fail rating on a standardized road test compared to older adults without preclinical AD, but the extent to which preclinical AD impacts everyday driving behavior is unknown. OBJECTIVE: To examine self-reported and naturalistic longitudinal driving behavior among persons with and without preclinical AD. METHOD: We prospectively followed cognitively normal drivers (aged 65 + years) with (n = 10) and without preclinical AD (n = 10) for 2.5 years. Preclinical AD was assessed using amyloid positron emission tomography (PET) with Pittsburgh Compound B. The Driving Habits Questionnaire assessed self-reported driving outcomes. Naturalistic driving was captured using a commercial GPS data logger plugged into the on-board diagnostics II port of each participant’s vehicle. Data were sampled every 30 seconds and all instances of speeding, hard braking, and sudden acceleration were recorded. RESULTS: Preclinical AD participants went to fewer places/unique destinations, traveled fewer days, and took fewer trips than participants without preclinical AD. The preclinical AD group reported a smaller driving space, greater dependence on other drivers, and more difficulty driving due to vision difficulties. Persons with preclinical AD had fewer trips with any aggression and showed a greater decline across the 2.5-year follow-up period in the number of days driving per month and the number of trips between 1–5 miles. CONCLUSION: Changes in driving occur even during the preclinical stage of AD. |
| Databáze: | OpenAIRE |
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