Triple therapy of intravitreal triamcinolone, photodynamic therapy, and pegaptanib sodium for choroidal neovascularization
| Autor: | Nauman A Chaudhry, G. Haffner, D. Tom, Juner Colina, P. E. Liggett |
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| Rok vydání: | 2006 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty Triamcinolone acetonide Visual acuity Porphyrins genetic structures Combination therapy medicine.medical_treatment Pegaptanib Visual Acuity Photodynamic therapy Triamcinolone Acetonide Injections Ophthalmology medicine Pegaptanib Sodium Humans Fluorescein Angiography Glucocorticoids Retrospective Studies Aged 80 and over Photosensitizing Agents business.industry Verteporfin Aptamers Nucleotide Acetonide eye diseases Choroidal Neovascularization Vitreous Body Choroidal neovascularization Treatment Outcome Photochemotherapy Drug Therapy Combination sense organs medicine.symptom business Tomography Optical Coherence medicine.drug |
| Zdroj: | American journal of ophthalmology. 142(6) |
| ISSN: | 0002-9394 |
| Popis: | Purpose To report the six-month results of subfoveal choroidal neovascularization that had been treated with combined therapy of high-dose intravitreal triamcinolone acetonide (HDIVTA), photodynamic therapy (PDT), and pegaptanib sodium injection. Design Retrospective, interventional case series study. Methods Medical files of 16 patients with this treatment were reviewed (22 eyes); 13 eyes had had previous treatment with HDIVTA and PDT; nine eyes were newly diagnosed choroidal neovascularization. Patients were treated with an injection of HDIVTA (10 mg), followed by PDT and pegabtanib sodium injection at two-week intervals. The main outcome variables were visual acuity (VA) and macular thickness by optical coherence tomography (OCT). Results The mean VA improved 2.2 lines ( P = .013 in the new treatment group); the previous treatment group (HDIVTA + PDT) improved only 0.7 lines ( P = 0.55, Wilcoxon ranked test). The mean of macular thickness before and after treatment was statistically significant in both groups. Conclusion This combination therapy showed improvement and/or stabilization in VA, particularly when used as first-line therapy. |
| Databáze: | OpenAIRE |
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