Residual HIV-specific CD4 and CD8 T cell frequencies after prolonged antiretroviral therapy reflect pretreatment plasma virus load
| Autor: | Luc Perrin, Elbe Ramirez, Sara J. Dawson, Marek Fischer, Catherine Fagard, Bernard Hirschel, Huldrych F. Günthard, David Price, Rodney E. Phillips, G. Scullard, Annette Oxenius, Jonathan Weber, Angela R. McLean |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
CD4-Positive T-Lymphocytes
Adult Male Anti-HIV Agents Anti-HIV Agents/ therapeutic use Immunology HIV Infections CD8-Positive T-Lymphocytes/ immunology CD8-Positive T-Lymphocytes Biology Virus Cohort Studies HIV-1/ immunology/isolation & purification Immune system Antigen Immunopathology Immunology and Allergy Cytotoxic T cell Humans CD4-Positive T-Lymphocytes/ immunology RNA Viral/blood Aged ddc:616 Immunity Cellular HIV Infections/drug therapy/ immunology/virology T lymphocyte Middle Aged Viral Load Virology CD4 Lymphocyte Count Infectious Diseases Viral replication HIV-1 RNA Viral Female CD8 |
| Zdroj: | AIDS, Vol. 16, No 17 (2002) pp. 2317-2322 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/00002030-200211220-00012 |
| Popis: | BACKGROUND: Virus-specific cellular immune responses mediated by CD4 and CD8 T lymphocytes are thought to be central to the effective control of HIV-1 replication in vivo. However, quantitative correlations between HIV-specific T lymphocyte frequencies and plasma virus load (pVL) have proved difficult to establish in infected human individuals. This most likely reflects the complex interactions between the virus and these immune effector cells in the absence of treatment. OBJECTIVE: To assess frequencies of HIV-specific T lymphocytes after prolonged suppression of viral replication, i.e., under conditions where the effects of virus on the immune response are standardized and minimized, thereby fixing an important variable in a dynamic multivariate system. METHODS: HIV-specific CD4 and CD8 T lymphocyte frequencies were measured in 122 individuals after prolonged periods of successful combination antiretroviral therapy (ART) administered during chronic HIV-1 infection. RESULTS: The residual frequency of both CD4 and CD8 T lymphocytes specific for HIV-1 was inversely related to the pretreatment pVL. This relationship appeared to be non-linear, indicating the presence of a threshold pretreatment pVL level above which HIV-specific CD4 and CD8 T lymphocyte responses could not be maintained when antigenic drive was suppressed. Substantial populations of functional HIV-specific CD4 and CD8 T lymphocytes were generally detectable after prolonged ART only in those individuals with a pretreatment plasma HIV-1 RNA < 100,000 copies/ml. CONCLUSION: These findings identify a quantitative immune associate of host-virus interactions in established HIV-1 infection. |
| Databáze: | OpenAIRE |
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