Plasma met-enkephalin levels in diabetic patients: Influence of autonomic neuropathy
| Autor: | M. D'Alessandro, M. Negri, F. Fallucca, N. Di Biase, G. Tonnarini |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Met-enkephalin endocrine system medicine.medical_specialty endocrine system diseases Enkephalin Methionine Endocrinology Diabetes and Metabolism Asymptomatic chemistry.chemical_compound Endocrinology Diabetic Neuropathies Diabetes mellitus Internal medicine medicine Humans Opioid peptide business.industry Pancreatic islets nutritional and metabolic diseases Middle Aged medicine.disease Pathophysiology Diabetes Mellitus Type 1 Peripheral neuropathy medicine.anatomical_structure Diabetes Mellitus Type 2 chemistry Metabolic control analysis Female medicine.symptom business |
| Zdroj: | Metabolism. 45:1065-1068 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/s0026-0495(96)90004-9 |
| Popis: | The presence of opioid peptides within pancreatic islets in several animal species and in humans suggests that these peptides could play a role in pancreatic endocrine secretion, influencing glucose metabolism. We measured plasma met-enkephalin (met-Enk) levels in eight neuropathic (four with insulin-dependent diabetes mellitus [IDDM] and four with non-insulin-dependent diabetes mellitus [NIDDM]) and eight nonneuropathic (four IDDM and four NIDDM) diabetic patients to study met-Enk secretion in diabetic patients with asymptomatic autonomic neuropathy. Plasma met-Enk levels were significantly lower in neuropathic compared with nonneuropathic patients both in the IDDM group (28.7 +/- 4.8 v 61.6 +/- 4.1 pg/mL, P < .0025) and in the NIDDM group (26.5 +/- 3.6 v 44.3 +/- 4.6 pg/mL, P < .0125). This study suggests that the presence of neuropathy in diabetic patients, even if asymptomatic, is associated with a significant decrease of plasma met-Enk levels, thus contributing to a worsening of metabolic control under stress conditions. |
| Databáze: | OpenAIRE |
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