Sirolimus treatment for cirrhosis or hepatocellular carcinoma patients accompanied by psoriasis after liver transplantation: A single center experience
| Autor: | Xian‑Jie Shi, Shao‑Zhen Yang, Li‑Kui Feng, Yong‑Gen Zheng, Zhi‑Jia Liu, Guo‑Sheng Du, Meng Xuan, Li‑Chao Pan, Lin Zhou, Hai‑Da Shi, Zhi‑Dong Zhu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Cirrhosis Basiliximab medicine.medical_treatment Liver transplantation Single Center Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Psoriasis medicine tacrolimus immunosuppression liver transplantation business.industry Immunosuppression Articles medicine.disease 030104 developmental biology sirolimus Methylprednisolone Hepatocellular carcinoma business psoriasis treatment medicine.drug |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1074 |
| Popis: | There is currently no consensus on the most suitable therapeutic approach for psoriasis (PS) co-existing with posthepatic cirrhosis (PCs) and hepatocellular carcinoma (HCC) following liver transplantation (LT). The present study provides an analysis of the therapeutic experience of such patients. Five LT recipients (two with PC and three with HCC) with accompanying PS were included. The induction program consisted of methylprednisolone plus basiliximab treatment. The initial postoperative treatment scheme consisted of tacrolimus (FK506) plus mycophenolate mofetil (MMF) and hormone; the latter was withdrawn 1 week after LT. The patients with PC had been using FK506 with or without a postoperative MMF program; the patients with HCC and recurrence of PS had been switched to a sirolimus (SRL)-based replacement therapy. Furthermore, all patients received anti-hepatitis B virus (HBV) therapy. The patients were followed up after 8.3±1.5 years. There was a positive correlation between HBV-DNA copy numbers, and psoriatic area and severity index (PASI) scores (r=0.97; P=0.006). The PASI scores were decreased significantly at 6 months following surgery compared with pre-transplantation (P |
| Databáze: | OpenAIRE |
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