ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type
| Autor: | Heleen Van Melckebeke, Karen Leroy, Barbara Vanhoecke, Jean-Philippe Jais, Sofie Lust, Fabrice Jardin, Josette Brière, Jerina Boelens, Fritz Offner, Jan Philippé, Marc Bracke, Ilse M. Beck |
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| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Cell Apoptosis Cell Line Tumor Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor medicine Humans Cyclophosphamide B cell Membrane Glycoproteins business.industry Germinal center Hematology Endoplasmic Reticulum Stress medicine.disease Lymphoma medicine.anatomical_structure Oncology Doxorubicin Vincristine Cell culture Unfolded Protein Response Unfolded protein response Cancer research Prednisone Lymphoma Large B-Cell Diffuse business Diffuse large B-cell lymphoma |
| Zdroj: | Leukemia Research. 37:3-8 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2012.08.017 |
| Popis: | The process of B-cell development is characterized by the activation of the unfolded protein response. Under certain circumstances, the unfolded protein response can be manipulated in a cell death-inducing way. Therefore, tackling the unfolded protein response might be an attractive strategy in the treatment of diffuse large B-cell lymphomas. Our research showed more basal unfolded protein response activity and differences in the inducibility of ER stress in activated B-cell versus germinal center cell lines. Moreover, the diffuse large B cell lymphoma patient data revealed that the glucose-regulated protein 94 is new potential discriminator for diffuse large B cell lymphoma. |
| Databáze: | OpenAIRE |
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