Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients
| Autor: | Gary E. Gibson, Parvesh Bubber, V. Hartounian, John P. Blass |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Citric Acid Cycle Prefrontal Cortex Biology Malate dehydrogenase Aconitase Article Mice Malate Dehydrogenase Internal medicine medicine Animals Humans Citrate synthase Pharmacology (medical) Biological Psychiatry Aged Aconitate Hydratase Aged 80 and over Pharmacology Sex Characteristics Succinate dehydrogenase Brain Middle Aged Pyruvate dehydrogenase complex Succinate Dehydrogenase Citric acid cycle Psychiatry and Mental health Glucose Endocrinology Isocitrate dehydrogenase Neurology Biochemistry Fumarase Schizophrenia biology.protein Female Neurology (clinical) Oxidation-Reduction |
| Zdroj: | European Neuropsychopharmacology. 21:254-260 |
| ISSN: | 0924-977X |
| Popis: | Images of brain metabolism and measurements of activities of components of the electron transport chain support earlier studies that suggest that brain glucose oxidation is inherently abnormal in a significant proportion of persons with schizophrenia. Therefore, we measured the activities of enzymes of the tricarboxylic (TCA) cycle in dorsolateral-prefrontal-cortex from schizophrenia patients (N=13) and non-psychiatric disease controls (N=13): the pyruvate dehydrogenase complex (PDHC), citrate synthase (CS), aconitase, isocitrate dehydrogenase (ICDH), the alpha-ketoglutarate dehydrogenase complex (KGDHC), succinate thiokinase (STH), succinate dehydrogenase (SDH), fumarase and malate dehydrogenase (MDH). Activities of aconitase (18.4%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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