Brain levels of 5-hydroxytryptamine, tryptamine and 2-phenylethylamine in the rat after administration of N-cyanoethyltranylcypromine
| Autor: | Ronald T. Coutts, Adil J. Nazarali, Glen B. Baker, T. W. Hall, Ronald G. Micetich |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Tryptamine Serotonin medicine.medical_specialty Chromatography Gas Monoamine oxidase medicine.medical_treatment Intraperitoneal injection chemistry.chemical_compound Capillary column Internal medicine Phenethylamines medicine Animals Biological Psychiatry Brain Chemistry Pharmacology Control level Chemistry N-2-cyanoethyltranylcypromine Drug administration Rats Inbred Strains Rat brain Tryptamines Rats Endocrinology Biochemistry Tranylcypromine |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 8:657-660 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/0278-5846(84)90031-9 |
| Popis: | 1. Brain levels of 5-hydroxytryptamine (5-HT), tryptamine (T), 2-phenylethylamine (PEA) and monoamine oxidase activity at 5, 15, 30, 60, 120 and 240 min were determined in male Sprague-Dawley rats after intraperitoneal injection of the “pro-drug” N-2-cyanoethyltranylcypromine (CE-TCP, dose 0.1 mMole/kg). 2. Analyses of 5-HT, T and PEA were performed on an electron-capture gas Chromatograph with a capillary column. Activity of MAO-A and MAO-B was measured using a radiochemical method. 3. Results indicate substantial inhibition of MAO in rat brain after intraperitoneal administration of CE-TCP, leading to elevated levels of 5-HT, T and PEA as early as 5 min after drug administration. 4. Increases in brain levels of the trace amines T and PEA were much greater (approximately 40 and 100 times control levels, respectively) than with 5-HT (approximately 1.8 times control level) 240 min after administration of CE-TCP. |
| Databáze: | OpenAIRE |
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