Multifunctional 'ball-rod' Janus nanoparticles boosting Fenton reaction for ferroptosis therapy of non-small cell lung cancer

Autor:	Guang Zhu, Hao Chi, Meichen Liu, Yalin Yin, He Diao, Zicheng Liu, Zhaoming Guo, Weiping Xu, Jianqiang Xu, Changhao Cui, Xiao-Jin Xing, Kun Ma
Rok vydání:	2022
Předmět:	Biomaterials Lung Neoplasms Colloid and Surface Chemistry Carcinoma Non-Small-Cell Lung Cell Line Tumor Ferroptosis Humans Nanoparticles Antineoplastic Agents Hydrogen Peroxide Multifunctional Nanoparticles Surfaces Coatings and Films Electronic Optical and Magnetic Materials
Zdroj:	Journal of Colloid and Interface Science. 621:12-23
ISSN:	0021-9797
DOI:	10.1016/j.jcis.2022.04.021
Popis:	Ferroptosis is a newly found cell death mechanism, which could bypass apoptosis and reverse multidrug resistance of tumors. However, efficient induction of tumor ferroptosis remains a challenge. In this study, multifunctional "ball-rod" Janus nanoparticles (FTG/LSMD) were constructed for non-small cell lung cancer (NSCLC) ferroptosis treatment. Protected by tannic acid (TA), FTG/LSMD maintains long-term function in blood circulation, while modification by 2, 3-dimethylmaleic anhydride (DMMA) confers the FTG/LSMD with pH-responsive charge reversal. Glucose oxidase (GOD) on FTG/LSMD catalyzes glucose to produce H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5813bd09bb7c4fbae05510fc59f1159e https://doi.org/10.1016/j.jcis.2022.04.021 Zobrazit plný text záznamu Full Text from ScienceDirect