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Kryvoruchko I. A., Goni S.- K. T., Antonova M. S., Sykal M. A., Voronaja U. M., Alexandrov M. A., Lola N. V. Modern methods of stimulation of angiogenesis in patients with critical limb ischemia (review). Journal of Education, Health and Sport. 2017;7(4):733-745. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.583314 http://ojs.ukw.edu.pl/index.php/johs/article/view/4464 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 12.04.2017. Revised: 10.04.2017. Accepted: 25.04.2017. MODERN METHODS OF STIMULATION OF ANGIOGENESIS IN PATIENTS WITH CRITICAL LIMB ISCHEMIA (REVIEW) I. A. Kryvoruchko, S.- K. T. Goni, M. S. Antonova, M. A. Sykal, U. M. Voronaja, M. A. Alexandrov, N. V. Lola Kharkov National Medical University, Ukraine Department of Surgery №2 Abstract The term "critical ischemia of extremities" (critical limb ischemia) was first introduced by P.R.F. Bell in 1982 to refer to a group of diseases accompanied by pain in the legs at rest, trophic ulcers and distal necroses of the lower limbs. Critical ischemia of the lower limbs is a condition of almost complete cessation of arterial blood flow to the tissues of the lower limbs. If the arterial blood supply is not improved, limb amputation becomes inevitable for all patients. Treatment of ischemia of the lower extremities should be complex and differentiated depending on the stage and features of the course of the disease. Modern approaches to the therapy of lower limb ischemia include conservative and surgical methods of treatment, all of which are aimed at improving blood flow in the affected limbs. In the article modern methods of stimulating angiogenesis in patients with lower limb ischemia and results are shown. Keywords: critical limb ischemia, cell therapy, gene therapy, angiogenesis stimulation |
