Synthetic cathinones – From natural plant stimulant to new drug of abuse
| Autor: | Rafał Skowronek, Ewelina Pieprzyca, Piotr Czekaj, Ľuboš Nižnanský |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pharmacology Drug Psychotropic Drugs Illicit Drugs Synthetic Drugs business.industry medicine.medical_treatment media_common.quotation_subject Context (language use) Catha Europe Stimulant 03 medical and health sciences Alkaloids 030104 developmental biology 0302 clinical medicine Environmental health medicine Humans Illicit drug Central Nervous System Stimulants business 030217 neurology & neurosurgery media_common |
| Zdroj: | European Journal of Pharmacology. 875:173012 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2020.173012 |
| Popis: | As recreational substances, synthetic cathinones started to be used at the beginning of the 21st century. There is still limited data on these compounds, introduced to the illicit drug market for the most part after 2009. Considering that synthetic cathinones are currently the second largest group of new psychoactive and dangerous substances among over 670 new psychoactive substances identified in Europe and monitored by the EMCDDA, research on them should be regarded as extremely important. This review focuses on the availability of synthetic cathinones on the illicit drug market, presentation of current trends in the use of these substances, and their mechanisms of action and toxicity. The authors discuss cases of intoxication with synthetic cathinones and post-mortem diagnostics as well as the problem of combined used of synthetic cathinones with other psychoactive substances. Literature as well as clinical and forensic data indicate the need for further research on the metabolism, toxicokinetics, toxicodynamics, clinical effects, and addictive potential of synthetic cathinones, especially in the context of potential threats caused by increased consumption of this group of drugs in future. |
| Databáze: | OpenAIRE |
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